doi:10.1016/j.jcjd.2024.08.002 Bjerre Knudsen L, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, et al
Variants in GIPR (the GIP receptor relevant to tirzepatide), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide
Based on such findings, guideline-directed medical therapy currently recommends SGLT2 inhibitors for people with type 2 diabetes mellitus who are at risk for HF, have pre-HF, or have established HF [92]
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