Leptin promotes the synthesis of anorexigenic peptides and counterbalances the effects of ghrelin
Li Y, Sun W, Han S, Li J, Ding S, Wang W, Yin Y (2016) IGF-1-involved negative feedback of NR2B NMDA subunits protects cultured hippocampal neurons against NMDA-induced excitotoxicity
The different ones GI discontinuation rate: 5.6% of semaglutide (Wegovy) users stopped due to GI side effects, vs 2.7% of Tirzepatide (Mounjaro) users Diarrhoea: Common with Mounjaro because of its dual action Nausea and constipation: Seen more in Wegovy MHRA NAION warning (February 2026) : Both medications carry an updated warning about a very rare but serious eye condition (non-arteritic anterior ischaemic optic neuropathy)
If your body is not operating at its full potential due to low levels of this vitamin, B12 shots are an effective, high-impact way to get a direct dose of cobalamin (active B12) into your system, straight into the muscle
For heartburn : Famotidine (Pepcid) reduces stomach acid