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Identified cellular targets through which PKA activation produces a bronchodilator effect include: MLCK: Phosphorylation of myosin light chain kinase (MLCK) by cAMP-dependent protein kinase (PKA) decreases the affinity of the kinase for Ca2+ and calmodulin , resulting in a decrease in MLCK activity
Three independent points were selected in the renal cortex (1 mm below the capsule, targeting tubule-rich regions to enhance Ksp promoter-mediated specificity), with 1015 l virus (2.5 10 v.g.) injected slowly over 1015 s per point to avoid excessive pressure
10.3390/plants9080946 52 LeeS.ChoiB
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