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As well, in real-world scenarios, such as described by Brindisi et al, it is mentioned a reduction in pleasure and taste perception in overweight and people with obesity with poor type 2 diabetes control, probably by lowering the detection threshold of sweet flavors, becoming more sensitive to them, resulting in aversion for this flavor (175)
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Long-Term Considerations Monitor for thyroid C-cell tumors in high-risk patients (family history), though human data remains reassuring
From a therapeutic point of view, these strategies suffer from the problem how to administrate these molecules to receive an efficient uptake in the tumour cells
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