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The IC50 values of 2-H-5-M-3-N against LC-2/ad, PC-14, and HLC-1 cell lines were 475, 250, and 691 g/ml, respectively
World Journal of Gastroenterology , 10 (7), 1032.
Up to 50% of malignant peripheral nerve sheath tumors arise in patients with neurofibromatosis type 1 (NF1), fewer than 10% of malignant peripheral nerve sheath tumors are radiation associated, and the remainder are without a known genetic predisposition ('sporadic' form)
GLP-1R plays a critical role in the signaling cascades leading to insulin release in response to an increase in blood glucose levels
FDA status: Investigational New Drug, without marketing authorization
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