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14 Two therapeutic strategies currently exist to overcome the short half-life of incretin hormones and pharmacologically augment the incretin effect: 1) inject GLP-1 receptor agonists that are resistant to degradation by the DPP-4 enzyme and 2) orally administer DPP-4 inhibitors that delay the enzymatic degradation of naturally secreted incretin hormones ( Figure 2 )

Timing hydration and electrolyte intake around GLP-1 injection days may help reduce dizziness, especially when nausea or reduced appetite disrupt normal eating patterns

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Together, they help lower blood sugar levels more effectively than either medication alone, especially when used alongside diet and exercise

Five databases (PubMed, Embase, Web of Science, Scopus, and Cochrane Library) were searched up to September 30, 2025