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For biosynthesis, it seems the only strategy to prolong the half-life is a ligand fused with a terminal albumin or Fc domain, whose critical points are length and location
Trobisch at Synergy
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Patients received chemotherapy with four cycles of doxorubicin and cyclophosphamide every 21 days, followed by weekly paclitaxel treatments for 12 weeks, combined with either 600 mg oral lipoic acid daily or a placebo for six months
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