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10.1002/ajmg.b.32421 28 KomatsuM.WaguriS.UenoT.IwataJ.MurataS.TanidaI.et al
The tripeptide glutathione, -L-glutamyl-L-cysteinyl-glycine, has come to the forefront as a nutritional bioactive with potential use in the management of NAFLD, as it plays a critical role in cellular antioxidant and detoxification systems
The MTHFD1L encoded enzyme is a mono-functional enzyme with 10-formyl-THF synthetase activity and the MTHFD2L encoded enzyme is a bi-functional enzyme with 5,10-methylene-THF dehydrogenase and 5,10-methenyl-THF cyclohydrolase activities