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The neutrophil elastase also increases factor Xa activity and binds to factor XII to stimulates fibrin formation and protein C inhibition by histone through thrombomodulin accelerate the magnitude of fibrin generation [36, 37]

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doi: 10.1016/j.cell.2009.04.037 157 LiTKonNJiangLTanMLudwigTZhaoYet al