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Patients with pre-existing heart failure who experience an increased heart rate with semaglutide and other GLP-1 agonist drugs are potentially at risk of their heart failure worsening, Dr
Although there is no absolute contraindication to using both medications together, their opposing metabolic effectsparticularly on appetite, weight, and blood glucoserequire careful monitoring and individualised management
The cardiovascular safety data deserves mention
Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients
Schulthess J, Pandey S, Capitani M, Rue-Albrecht KC, Arnold I, Franchini F, Chomka A, Ilott NE, Johnston DGW, Pires E, McCullagh J, Sansom SN, Arancibia-Crcamo CV, Uhlig HH, Powrie F
