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Activated microglia drive the immune response to the inflammatory state releasing immune signaling molecules (cytokines, and chemokines), and inducing neuronal cell death ( These data underline the importance of optimal glycemic control and call for major pharmacological interventions to reduce the risk of cardiometabolic-related cognitive impairment
Nat Chem Biol 18:109115
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This approach can reduce peak drug levels and may improve tolerability
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