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To explore the mechanism by which pasireotide acts on intestinal L-cells, we investigated the impact of DCA, or a nutrient mimicking our daily meals, on GLP-1 secretion from GLUTag cells

insulin glargine The SURPASS-AP-Combo trial enrolled 917 adults with type 2 diabetes (age 18 years, inadequately controlled by previous metformin therapy and insulin-naive), who received tirzepatide 5 mg (n = 230), 10 mg (n = 228), 15 mg (n = 229), or insulin glargine (n = 230)

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In addition, early data suggests possible renal protection