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Only case reports, case series, retrospective chart reviews, open-label trials, and randomized controlled trials (RCTs) were considered

Here we studied the effects of semaglutide on the circulating proteome using baseline and end-of-treatment serum samples from two phase 3 trials in participants with overweight or obesity, with or without diabetes: STEP 1 ( n = 1,311) and STEP 2 ( n = 645)

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Pharmacokinetics: administered as eye drops, or topically to the skin does not readily cross the blood brain barrier due to a low lipid solubility