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Emerging mechanisms include next-generation Janus kinase and tyrosine kinase 2 inhibitors with enhanced selectivity, novel cell trafficking modulators, advanced tumor necrosis factor-alpha inhibition strategies, and selective interleukin-23 pathway antagonists
Classically hepatocyte hypertrophy occurs without increase in hepatocyte numbers or DNA (i.e., hyperplasia or polyploidy), however, combinations with increased mitoses do occur (e.g., PPAR-alpha agonists)
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