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Consistently, colibactin-related mutational signatures have been identified in human CRC genomes [145, 146], while inhibition of its biosynthesis or blockade of adhesin-mediated epithelial binding can attenuate its genotoxic and tumor-promoting effects [147, 148]
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During a 12-month study, a decrease in heart failure and death was observed among those taking L-carnitine supplements
The majority of clinical investigations conducted thus far are characterized by limited sample sizes, abbreviated intervention periods, and diverse study designs, thereby complicating the establishment of optimal dosing regimens, timing of administration, and the effective combinations of these therapeutic modalities
Psychologically, the constant monitoring of blood glucose levels, adherence to strict dietary restrictions, and regular antidiabetic medication or insulin use contribute to considerable psychological stress and can lead to anxiety and depression [114, 115]
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