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In addition, riboflavin and pyridoxine, which requires riboflavin for its activation, have been shown to have intrinsic neuroprotective properties against glutamate excitotoxicity
BCNU treatment significantly increased cellular GSSG levels without affecting GSH levels (Fig
(2021) demonstrated that MOTS-c levels decline with age in both mice and humans, and that exogenous MOTS-c administration improved physical capacity in aged mice without observable toxicity over a 2-week treatment window [5]
The recommended starting dose is 2.5 mg weekly for the first four weeks to assess tolerability
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