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It plays integral roles in: Immune regulation Cancer suppression (anti-proliferative and pro-apoptotic signaling) Mitochondrial function and redox balance Hormonal feedback loops, including cortisol and estrogen/testosterone rhythms Aging diminishes melatonin output by up to 75%, leading to weaker circadian cues and downstream systemic dysfunction

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Development of an in vivo murine model to evaluate the efficacy of small molecule inhibitors for the treatment of leukemic cells with activated MAPK/ERK signaling

This phase, lasting approximately 10 days, serves as the bridge between growth and rest

Researchers started every participant at the same base dose regardless of their target maintenance level, then increased the dose every four weeks until reaching the assigned tier