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Current clinical evidence for possible antidepressant effects of GLP-1R agonists Depression is often comorbid with metabolic disorders such as T2DM and obesity and many antidiabetic drugs, which often display neuroprotective and immunomodulatory effect, have demonstrated antidepressant properties in clinical trials
Association of bile duct and gallbladder diseases with the use of incretin-based drugs in patients with type 2 diabetes mellitus
Nutrients 15 (8), 1848
Activation of SIRT1 improves insulin sensitivity and regulates blood glucose level: SIRT1 can directly deacetylate and activate peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), thereby promoting mitochondrial biogenesis and enhancing cellular energy efficiency, which in turn strengthens tissue responsiveness to insulin [107]
PMID 21281406
