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Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels

This is the core of the B12 oral vs injection question

5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) is a small molecule compound identified in scientific literature as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolic pathways

Its molecular structure is characterized by: An aromatic ring system An amino group that contributes to its reactivity A methylquinolinium moiety that influences its physicochemical properties The structural features of 5-amino-1mq have been well-documented and studied, providing researchers with a wealth of information about its behavior in biological systems

Over-methylation Over-methylation occurs when there is too much SAM in circulation