antagonist glp 1 GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology GLP-1 Agonists and Antagonists |

Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Links RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Natural products OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 107 108010024636 Glutathione Proteins 0.000 claims abstract description 70 229960003180 glutathione Drugs 0.000 claims abstract description 35 -1 glutathione thiol Chemical class 0.000 claims abstract description 17 239000000126 substance Substances 0.000 claims abstract description 10 150000001413 amino acids Chemical class 0.000 claims abstract description 8 239000003814 drug Substances 0.000 claims abstract description 7 239000004065 semiconductor Substances 0.000 claims abstract description 3 239000011782 vitamin Substances 0.000 claims abstract description 3 229930003231 vitamin Natural products 0.000 claims abstract description 3 235000013343 vitamin Nutrition 0.000 claims abstract description 3 229940088594 vitamin Drugs 0.000 claims abstract description 3 150000003722 vitamin derivatives Chemical class 0.000 claims 1 238000002560 therapeutic procedure Methods 0.000 abstract description 20 230000002829 reductive effect Effects 0.000 abstract description 9 230000019522 cellular metabolic process Effects 0.000 abstract description 5 210000004027 cell Anatomy 0.000 description 39 235000003969 glutathione Nutrition 0.000 description 31 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 30 239000001301 oxygen Substances 0.000 description 21 229910052760 oxygen Inorganic materials 0.000 description 21 102000004190 Enzymes Human genes 0.000 description 16 108090000790 Enzymes Proteins 0.000 description 16 QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 15 208000035475 disorder Diseases 0.000 description 15 238000011282 treatment Methods 0.000 description 15 201000010099 disease Diseases 0.000 description 14 230000006870 function Effects 0.000 description 13 238000007254 oxidation reaction Methods 0.000 description 13 241001465754 Metazoa Species 0.000 description 12 230000015572 biosynthetic process Effects 0.000 description 12 206010028980 Neoplasm Diseases 0.000 description 11 238000006243 chemical reaction Methods 0.000 description 11 UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 10 239000001257 hydrogen Substances 0.000 description 10 229910052739 hydrogen Inorganic materials 0.000 description 10 230000003647 oxidation Effects 0.000 description 10 210000001519 tissue Anatomy 0.000 description 10 210000004369 blood Anatomy 0.000 description 9 239000008280 blood Substances 0.000 description 9 230000003834 intracellular effect Effects 0.000 description 9 238000011321 prophylaxis Methods 0.000 description 9 150000003254 radicals Chemical class 0.000 description 9 108010053070 Glutathione Disulfide Proteins 0.000 description 8 201000011510 cancer Diseases 0.000 description 8 238000002474 experimental method Methods 0.000 description 8 YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 8 238000001802 infusion Methods 0.000 description 8 230000004060 metabolic process Effects 0.000 description 8 238000002360 preparation method Methods 0.000 description 8 230000001225 therapeutic effect Effects 0.000 description 8 108010063907 Glutathione Reductase Proteins 0.000 description 7 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 7 241000282412 Homo Species 0.000 description 7 238000010521 absorption reaction Methods 0.000 description 7 238000012360 testing method Methods 0.000 description 7 XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7 235000001014 amino acid Nutrition 0.000 description 6 230000037396 body weight Effects 0.000 description 6 230000006378 damage Effects 0.000 description 6 210000004379 membrane Anatomy 0.000 description 6 239000012528 membrane Substances 0.000 description 6 239000000243 solution Substances 0.000 description 6 102000006587 Glutathione peroxidase Human genes 0.000 description 5 108700016172 Glutathione peroxidases Proteins 0.000 description 5 241000699670 Mus sp

Goodman, M

The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases

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The gutgenital tract microbiota interface and immune crosstalk is a recognised concept in womens health, and diabetes is associated with alterations in vaginal microbiota ecology, particularly around menopause transitions