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Start: 500 mcg daily
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In the context of senescence, PD-1 and PD-L1 are overexpressed in several in vitro models induced by drugs or related to normal aging phenotype 45
For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors
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