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It is not simply a pain-relief peptide
The Receptor as a Dynamic Machine, Not a Switch Underlying the clinical heterogeneity in GLP-1 RA response is a biophysical reality that the prevailing pharmacological framework has underestimated: the GLP-1R is not a binary on/off transducer
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Therefore, it cannot be fully excluded that some of the transcriptional, metabolic, and anti-fibrotic changes observed in adipose tissue may represent secondary adaptations to reduced fat mass rather than exclusively direct pharmacological effects
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