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Despite the lack of extra support for lifestyle modification as part of the SURPASS program, 4069% of patients achieved 10% weight loss with the highest doses of tirzepatide (1015 mg), which ranged from 9.5 kg to 12.9 kg [100]
When your appetite is suppressed and youre eating significantly less, youre also losing a major source of hydration without necessarily feeling thirsty enough to compensate with additional fluid intake
Therefore, precise characterization of hemodynamic abnormalities and implementation of multi-targeted therapeutic strategies are essential for interrupting disease progression and preserving long-term kidney function in patients with DKD
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