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Knudsen, who is now a chief scientific adviser at Novo Nordisk, told STAT that based on mouse studies her team has conducted, the more dramatic weight loss is most likely a result of the fact that semaglutides chemical structure makes it easier to slip into the brain, particularly into areas involved with signaling feelings of fullness

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Phase 2 trials reported 24.2% average bodyweight loss at highest doses over 48 weeks (NEJM)