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MK-677 represents a different single-compound approach entirely

Notably, our previous research highlighted how individuals with T2D initiate GLP-1 RA treatment at lower A1c and BMI levels in more recent years (Cartwright et al., 2024), reflecting a trend toward broader and more accessible use of these drugs

Collection and preparation of plasma, liver, and kidney specimens for metabolomics Blood was obtained via cardiac puncture and centrifuged at 3000 g at 4 C for 10 min