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First, some peptides are synthesized by solid-phase synthesis or liquid-phase synthesis, and then the remaining peptides are synthesized by synthetic biology methods

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In vitiligo patients, an increase in pro-inflammatory cytokines typical of innate immunity, IL IL-1, IL-1, IL-6, IL-8, IL-12, IL-15, and TNF-, is observed in both serum and skin.2,3 Damage-associated molecular patterns The Koebner phenomenon is considered an initial trigger for vitiligo