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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
PMID 14223080
PubMed Philp, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A.L., Kleinman, H.K
It appears in human plasma at approximately 200 ng/ml in young subjects, with a drop of more than 60 % between ages 20 and 60, an observation that motivated forty years of research on its role in tissue repair, wound healing, hair growth and cutaneous longevity
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