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Induction of phase 2 enzymes occurs through antioxidant response element-driven gene expression, with targets including NAD(P)H:quinone reductase, heme oxygenase 1, and gamma-glutamylcysteine synthetase regulated by nuclear factor E2 related factor (13)

A third pathway, the olfactory nerve route to the brain, is distinct and does not guarantee systemic circulation

Brain uptake of S-(12-dichlorovinyl)glutathione and S -(12-dichlorovinyl)- L -cysteine, the glutathione and cysteine S -conjugates of the neurotoxin dichloroacetylene

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