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The standard dose is 1000 mcg, given as an intramuscular or subcutaneous injection

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Early haematological response begins with reticulocytosis (increased production of immature red blood cells) typically by day 3-4 of treatment , particularly with injectable forms, though the full resolution of symptoms may take several weeks to months

"The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity"