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These medications are primarily prescribed for long-term blood sugar control in patients with type 2 diabetes
In the same trial, 1-8% of patients reported injection site reactions with retatrutide, while no case was reported in the placebo group
10.1016/j.ophtha.2025.01.016 2 ArabH
N Engl J Med 381:19952008 Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, Januzzi J, Verma S, Tsutsui H, Brueckmann M, Jamal W, Kimura K, Schnee J, Zeller C, Cotton D, Bocchi E, Bhm M, Choi DJ, Chopra V, Chuquiure E, Giannetti N, Janssens S, Zhang J, Gonzalez Juanatey JR, Kaul S, Brunner-La Rocca HP, Merkely B, Nicholls SJ, Perrone S, Pina I, Ponikowski P, Sattar N, Senni M, Seronde MF, Spinar J, Squire I, Taddei S, Wanner C, Zannad F (2020) EMPEROR-Reduced Trial Investigators
In the studied context, a review of six clinical trials found a safety profile comparable to placebo, without the IGF-1 effects of full growth hormone
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