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These findings suggest that targeting the JAK/STAT axis could provide a dual benefit in HS by attenuating both inflammation and fibrosis, while also addressing the contribution of adipose tissue-derived mediators to these pathogenic mechanisms (Table 2)
Ultimately, thats something for the patient and their prescribing doctor to decide, but I would do my part to inform them about the findings of the recent study, Rahimy said
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It may be, What do you know about your family? You get some genetic assessment, whether it's whole genome sequencing or polygenic risk score, then you start to look at the protein layer and particular biomarkers
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