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It's critical because it: Minimizes side effects like nausea and GI discomfort Lets your body adjust to the medication Helps find your optimal therapeutic dose Most patients step up roughly every 4 weeks over a 1216 week schedule until reaching a maintenance dose which keeps side effects down while supporting results

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Refer to the product label for dosing instructions, age-appropriateness, and relative risk statements

These include things like gallstones or biliary colic, said Goldenberg

Figure S24