However, the weight loss effect often stalls shortly after starting, and upon discontinuation (whether planned or due to difficulties in accessing the medication or its cost), weight often returns to previous levels, and sometimes even higher, very quickly
A researcher on a 4mg weekly protocol who splits into three injections is taking approximately 1.33mg per injection
Some weight-loss clinics offer vitamin B12 injections as part of their weight-loss program
However, due to the insufficiency of clinical evidence, it cannot be used as a first-line treatment drug at present
Headache worse lying down (the more common GLP-1 pattern): Suggests relative CSF volume depletion Brain is inadequately cushioned Lying down increases intracranial pressure, stretching pain-sensitive structures Standing allows CSF to drain, reducing pressure Fix: hydration to restore CSF volume Headache worse standing up (less common, but possible): Suggests CSF leak or severe volume depletion Brain sags downward when upright due to inadequate CSF support Lying down allows the brain to float properly again Standing creates traction on meninges and cranial nerves Fix: aggressive hydration, possible imaging to rule out CSF leak The GLP-1 pattern is usually the first type (worse lying down) because the mechanism is relative hypervolemia when supine in the context of chronic mild dehydration