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"It is critical that we strive to generate the evidence needed both to inform obstetric care and guide treatment initiation decisions," the commentary authors concluded

5 Future directions The potential of GLP-1RAs as dual-action therapies, targeting both metabolic dysfunction and immune dysregulation, makes them particularly compelling candidates for early PsA, where intervention may alter disease trajectory

Topical evidence is stronger and includes IRB-approved human trials

That dissociation is the strongest practical argument for treating cerebrospinal fluid and plasma markers in these trials as exploratory readouts of target engagement rather than as stand-ins for benefit

A safe area should be outside of any building or vehicle and away from any combustible materials