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HEK293T cells were co-transfected with HA-tagged X(PC) and Flag-tagged procaspase-1-Cys285Ala, and protease activity was assessed by immunoblotting (Fig

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Suppression of SNAIL2, a zinc finger protein member of the SNAIL superfamily of epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) commonly overexpressed in pancreatic cancer patients, restored sensitivity of pancreatic cancer cell lines KLM1 and KMP5 to chemotherapy drug gemcitabine through an IGF binding protein 2 (IGFBP2)-dependent mechanism in vitro and in vivo (50)

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L-carnitine, however, could help with quicker recovery from that stress