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As estrogen fluctuates in perimenopause and declines in menopause, several things happen simultaneously: Insulin resistance increases Visceral fat storage becomes easier Muscle mass gradually declines Resting metabolic rate slows Sleep becomes more disrupted Cortisol becomes more reactive Insulin resistance alone can change everything
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Melanotan II functions similarly but works across multiple melanocortin receptors (MC1R, MC3R, MC4R), stimulating additional effects beyond tanning of the skin, including appetite suppression and sexual enhancement including libido enhancement
This dose results in exposures approximately 60 times the human exposure at the maximum recommended daily adult human dose (MRHD) of 100 mg/day based on AUC comparisons
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