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Expanding therapeutic indications beyond diabetes into obesity treatment multiplies the addressable market size
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Brent A McLean, Chi Kin Wong, Jonathan E Campbell, David J Hodson, Stefan Trapp, Daniel J Drucker Endocrine Reviews , First published online on December 15, 2020, bnaa032 Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and gut motility, supporting development of GLP-1 receptor (GLP-1R) agonists for the treatment of diabetes and obesity
To maximize both efficacy and tolerability, a gradual dose escalation protocol is often implemented
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