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Indeed, GLP-1RA therapy appears to be well tolerated overall, and proportions of clinical trial participants discontinuing treatment because of adverse events tend to be low (5.49.9%) [10, 37, 39, 43, 46, 47]

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Here we compare the published data from the STEP-1, SURMOUNT-1, and TRIUMPH-4 trials without marketing spin: -14,9% for semaglutide, -20,9% for the tirzepatide-28,7% for the retatrutideThe retatrutide vs tirzepatide vs semaglutide comparison also incorporates tolerance (dysesthesia 20,9% at the 12 mg dose level of retatrutide), pleiotropic effects 2024-2025 (apnea, heart failure, MASLD), and the updated regulatory status in France 2026

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