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AHR Adjusted hazard ratio ALA Alpha-lipoic acid -hCG Beta-human chorionic gonadotropins CAT Catalase CI Confidence interval CIPN Chemotherapy induced peripheral neuropathy CRC Colorectal cancer CoQ10 Coenzyme quotient 10 DNA Deoxyribose-nucleic acid EMT Epithelial-mesenchymal transition GPx Glutathione peroxidase HNSCC Head and neck squamous cell carcinoma HR Hazard ratio IVC Intra venous vitamin C IU International unit MTD Maximum tolerated dose NSCLC Non-small cell lung cancer PSA Prostate surface antigen QoL Quality of life RCT Randomized controlled trials ROS Reactive oxygen species RP2D Recommended phase 2 dose RR Relative risk RT Radiation therapy SOD Superoxide dismutase TMZ Temozolomide WHO World Health Organization Glossary References 1

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AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance