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168 As reviewed by Brierley & Kelber, compounds like gingerol, menthol, and eugenol target TRP channels (e.g., TRPA1, TRPM8), which are responsible for pain and motility regulation in the GI tract

Pigment storage is a consequence of colonic epithelial cells apoptosis, in which the apoptotic cells are swallowed by macrophages, which migrate in the lamina propria and the conversion into lipofuscin pigment occurs by lysosomal enzymes (19)

doi:10.1111/j.1365-2141.2005.05834.x

144 MitschkeJ.FussJ.BlumT.HglundA.ReskiR.KohlbacherO.et al (2009)

NSAID pain relievers are effective in curbing pain but do damage to a number of other body systems