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There were 17 NAION events in the GLP-1 group compared to 6 in the non-GLP-1 RA group
Interactions and underlying conditions: Concurrent medications that reduce saliva or medical conditions such as diabetes, neuropathy, or Sjgren syndrome can make dry mouth more likely while on tirzepatide
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Eli Lilly has also climbed over the same time frame, going up nearly 70% in stock price
These effects are largely attributable to the GLP-1 receptor agonist component of the drug, which slows gastric emptying and alters gut motility
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