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RCTs minimize bias and often provide the clearest answer to Does it work? But pay attention to study length and inclusion criteria short, tightly controlled trials may not reflect long-term or heterogeneous real-world patients

Our results report the first doseresponse relationship between osilodrostat dose and cortisol levels, which should be helpful in identifying the optimal dosing regimen in patients with Cushing's syndrome and in individualizing treatment to approximate a nychthemeral rhythm

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