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Animals developed persistent esophagitis with hemorrhagic lesions, thinned epithelium, and chronically reduced sphincter pressures lasting up to 20 months

It has also been discovered to be necessary for the development and maintenance of skeletal and muscle tissue, and to raise IGF-1, or Insulin-like Growth Factor 1

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Nonetheless, residual effects on gastric emptying could still produce significant gastrointestinal adverse effects in patients treated with long-acting GLP-RAs (167)

DPP-4 inhibitors: Generally discontinued when starting GLP-1 since both affect the incretin system