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Matrix Metalloproteinases (MMPs) and Their Inhibitors (TIMPs): The balance between MMPs (which break down the ECM) and TIMPs (which inhibit MMPs) is critical for tissue homeostasis

3.5.3 Microbial metabolites, immune modulation, and disease progression Altered microbial metabolism in CFS/ME extends beyond SCFAs

No Phase III anti-inflammatory endpoint

M1 macrophages are primarily characterized as inflammatory cells that possess the ability to eliminate invading pathogens and actively participate in a diverse range of antigen presentation processes (43)

USA 46 , 10441053 (1960)