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Factors specific to retatrutide that might affect real-world outcomes include: The higher side effect rate could drive more discontinuations The heart rate increase might concern prescribers and lead to lower maintenance doses If pricing is higher than tirzepatide, cost barriers could limit access and adherence The more complex triple-agonist mechanism may require more careful monitoring, adding burden Conversely, the additional metabolic benefits (liver fat reduction, possibly better muscle preservation) might improve adherence by providing visible results beyond scale weight, motivating continued use
After the collection of blood samples of the included subjects at 9 AM on the same day, this study further measured the serum levels of IGF-1 and IGF-BP-3 using immulite2000 Chemical luminescence immunity analyzer (Siemens, Germany)
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In addition, facial sallowness was assessed visually by trained evaluators using a 09 severity scale with 0.5-point increments: 0 = no visible sallowness
