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However, its application in topical formulations is severely hindered by its rapid oxidation, intrinsic instability, and poor permeability across the stratum corneum

To date, well over twenty different peptides have been studied and assessed for their ability to make a meaningful impact in the bone remodeling process

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Their method through the oscillating of microbubbles under the ultrasound field could implement the transport of the gene product beyond the blood vessels without breaking the tight junctions and disrupting the BBB