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In: Purich DL (ed) Advances in enzymologyand related areas of molecular biology
KPV, the C-terminal tripeptide of -MSH (Lys-Pro-Val), has been investigated for its interaction with NF-B signaling, with researchers observing inhibition of NF-B nuclear translocation and downstream inflammatory cytokine expression (TNF-, IL-6, IL-8) in cell culture models
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This is mainly due to the fact that research has traditionally focused on well-known stress molecules like SA or JA, or simply measured the activity of selected redox enzymes
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