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A notable study examining GHRH analog use in older adults over a 6-month period found no significant adverse events compared to placebo, while successfully increasing GH and IGF-1 levels

Researchers believe additional biological mechanisms contribute to these health benefits

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To reconcile the findings that both GIPR antagonists and GIPRAs reduce body weight, it is possible that physiological GIPR activity plays a permissive role in adipose tissue synthesis, while pharmacologically enhanced GIPR activity may reduce body weight through a different mechanism in the brain

Am J Dig Dis