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Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo (75)
However, absorption through the gastrointestinal tract remains a significant limitation
In our opinion, the sublingual or buccal route is likely to increase the bioavailability of glutathione better than oral tablets or capsules
However, pretty much every facet of modern-day life can contribute to draining our glutathione levels
In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]
