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Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E / insulin receptor substrate 2 +/ (APOE / irs2 +/ ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)
309 , F2F23 (2015)
The Evidence: Efficacy Beyond the Hype The first GLP-1 agonist, exenatide (Byetta, approved in 2005), required twice-daily injections and produced modest weight loss
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Although high-quality clinical studies directly reporting combination therapies as ineffective or harmful are uncommon, inconsistencies persist in the existing evidence
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